FOXP1-related disorder is characterized by a complex speech and language phenotype with prominent dysarthria, broader motor planning and programming deficits, and linguistic-based phonological errors. Diagnosis of the speech phenotype associated with FOXP1-related dysfunction will inform early targeted therapy.
Recognition for one of Australia’s top clinical medicine scientists, Professor Angela Morgan
Professor Angela Morgan has been recognised for her outstanding leadership in advancing the diagnosis, prognosis and management of childhood speech disorders.
Best practices for supervised machine learning when examining biomarkers in clinical populations
Redenlab CSO contributes to a new book chapter on the Best practices for supervised machine learning when examining biomarkers in clinical populations has been included in ‘Big Data in Psychiatry & Neurology’ published by Elsevier.
Characterization of dysphagia and longitudinal changes in swallowing function in adults with Niemann‑Pick disease type C treated with miglustat
Miglustat is currently the only approved disease-specific treatment shown to be effective in stabilizing neurological symptoms. Miglustat has previously been reported to halt or improve early dysphagia and cognitive symptoms. Here we examine the characteristics of dysphagia, the relationship between dysphagia and the presence of cognitive impairment, and longitudinal changes in swallowing function during miglustat treatment in adult-and-adolescent-onset NPC.
A cross-sectional study of perceptual and acoustic voice characteristics in healthy aging
Acoustic features that predict healthy aging are different than those previously reported for the pathologic voice. We propose a model of healthy and pathologic voice development in which voice characteristics are mediated by the inability to monitor vocal productions associated with age-related hearing loss.
Redenlab awarded new clinical trial with Top 10 Pharma company
Redenlab Inc. are pleased to announce securing clinical trial in Cyclic Vomiting Syndrome with a Top 10 pharma company. Redenlab are providing audio capture and analytics for a Phase 1b clinical trial. Conducted in sites across the USA, the study will investigate the long-term efficacy of a treatment designed to ameliorate the impact of this rare and debilitating disease.
A modeling-guided case study of disordered speech in minimally verbal children with autism spectrum disorder
Redenlab pediatric specialist Prof Angela Morgan co-authors a new study on speech models in minimally verbal children with autism spectrum disorder. The collaboration with scientists from Boston and Melbourne provides preliminary evidence that subphenotypes of children with MV ASD may exist.
Redenlab working as industry partner supporting a successful Australian Research Council Training Centre for Optimal Ageing
Redenlab are part of a successful consortium securing funding for training a new cohort of early career researchers in understanding key issues in optimal ageing (including environmental, social and economic factors that underlie health and independence in ageing).
Redenlab appoints eminent statistician Prof Geoff Stuart to lead its Statistics team
Dr Geoff Stuart joins the Redenlab analytics team as Statistics Director. Geoff will be running the company’s clinical trials statistics program and data analytics development. He brings expertise in mathematical statistics and a background in experimental psychology.
Sensitivity of acoustic measures extends to recreational users of cannabis
Subtle differences in speech timing, vocal effort, and voice quality were found between cannabis and control groups. After controlling for lifetime alcohol and tobacco use, the cannabis group presented with longer and more variable pauses across tasks, and vocal effort was different compared to controls. Vocal effort and intensity also appeared to change in line with duration of abstinence from cannabis use – that is, they appeared get better the longer they stayed away from the drug. The differences observed between users and controls may reflect longer term changes to the underlying neural control of speech.