Our LatestBlog & News

    The 4th Annual Kabuki Syndrome Foundation Research Conference to be held virtually on Friday, November 4, 2022. The Annual Conference...
      Join World BI and Redenlab for the 20th Clinical Trials Innovation Programme, to learn from experts in the drug development...
        The inaugural International Congress for Ataxia Research will be held on 1 - 4 November, Dallas. Featured topics include: gene...
          MEDIA RELEASEFRIDAY 15 JULY 2022 As many as 70% of people who experience stuttering have a family member who also...
            Marketing Specialist - REMOTE/WFH   DescriptionThe Marketing Specialist will support, improve, and implement technologies, systems, and processes for generating inbound...
              Subtle progressive changes in speech motor function and cognition begin prior to diagnosis of Huntington's disease (HD). Scientists at University...
                Face to face singing therapy can improve speech in PD. Have a look at our previous work published in Neurorehabilitation...
                  Rare genetically inherited neurodevelopmental disorders remain a huge diagnostic and therapeutic challenge in clinical medicine. Redenlab pediatric consultant Prof Angela...

                    Dr Garcia joins the Redenlab science team to drive its language analytics pipeline for cognitive-linguistic disorders like fronto-temporal dementia.

                      Atypical development of Broca’s area in a large family with inherited stuttering Stuttering (aka Stammering) is a neuro-motor disorder of...
                        We’re a speech science organisation focused on advancing the development of new treatments and enabling earlier clinical insights in healthcare....

                          Redenlab’s latest iOS application provides state of the art audio capture, storage and analysis of speech and language data for monitoring brain health.

                            Redenlab is contributing to a study sponsored by the Australian Department of Defence and The University of Melbourne on speech biometrics and decision making in submariners

                              Dr Amir Lahav hired as Chief of Digital Health and Strategy. He is a clinical neuroscientist and a leading innovator in digital health with a special focus on developing and validating novel biomarkers and AI-driven technology for remote monitoring of patients with neurodegenerative diseases.

                                What are the evidence-based recommendations to guide early intervention in children aged 0 to 2 years who have or are at high risk of cerebral palsy?

                                  Redenlab are presenting some of their work on Parkinson’s Disease and speech at the upcoming virtual Movement Disorders Society Conference...
                                    Over the past two decades, genomic studies have played an increasingly important role in exploring the history of our own...
                                      The Position Redenlab is seeking an experienced Quality Assurance Associate to join our growing Regulatory Affairs & Quality Assurance Team....

                                        Subtle differences in speech timing, vocal effort, and voice quality were found between cannabis and control groups. After controlling for lifetime alcohol and tobacco use, the cannabis group presented with longer and more variable pauses across tasks, and vocal effort was different compared to controls. Vocal effort and intensity also appeared to change in line with duration of abstinence from cannabis use – that is, they appeared get better the longer they stayed away from the drug. The differences observed between users and controls may reflect longer term changes to the underlying neural control of speech.

                                          Dr Geoff Stuart joins the Redenlab analytics team as Statistics Director. Geoff will be running the company’s clinical trials statistics program and data analytics development. He brings expertise in mathematical statistics and a background in experimental psychology.

                                            Redenlab are part of a successful consortium securing funding for training a new cohort of early career researchers in understanding key issues in optimal ageing (including environmental, social and economic factors that underlie health and independence in ageing).

                                              Redenlab pediatric specialist Prof Angela Morgan co-authors a new study on speech models in minimally verbal children with autism spectrum disorder. The collaboration with scientists from Boston and Melbourne provides preliminary evidence that subphenotypes of children with MV ASD may exist.

                                                Redenlab Inc. are pleased to announce securing clinical trial in Cyclic Vomiting Syndrome with a Top 10 pharma company. Redenlab are providing audio capture and analytics for a Phase 1b clinical trial. Conducted in sites across the USA, the study will investigate the long-term efficacy of a treatment designed to ameliorate the impact of this rare and debilitating disease.

                                                  Acoustic features that predict healthy aging are different than those previously reported for the pathologic voice. We propose a model of healthy and pathologic voice development in which voice characteristics are mediated by the inability to monitor vocal productions associated with age-related hearing loss.

                                                    Miglustat is currently the only approved disease-specific treatment shown to be effective in stabilizing neurological symptoms. Miglustat has previously been reported to halt or improve early dysphagia and cognitive symptoms. Here we examine the characteristics of dysphagia, the relationship between dysphagia and the presence of cognitive impairment, and longitudinal changes in swallowing function during miglustat treatment in adult-and-adolescent-onset NPC.

                                                      Redenlab CSO contributes to a new book chapter on the Best practices for supervised machine learning when examining biomarkers in clinical populations has been included in ‘Big Data in Psychiatry & Neurology’ published by Elsevier.

                                                        Professor Angela Morgan has been recognised for her outstanding leadership in advancing the diagnosis, prognosis and management of childhood speech disorders.

                                                          FOXP1-related disorder is characterized by a complex speech and language phenotype with prominent dysarthria, broader motor planning and programming deficits, and linguistic-based phonological errors. Diagnosis of the speech phenotype associated with FOXP1-related dysfunction will inform early targeted therapy.

                                                            Redenlab CSO, Adam Vogel, will be presenting at the upcoming ERN-RND joint webinar with the European Acadamy of Neurology and ERN EURO-NMD: Speech as a biomarker in Ataxia: What can it tell us & how should we use it?

                                                              The Position Redenlab is seeking an experienced Software Developer. Redenlab is one of the world’s leading providers of speech and...
                                                                Redenlab CSO, Adam Vogel, will be presenting at the upcoming joint webinar with the European Reference Network for rare or...

                                                                  SpeechATAXIA is a multi-language, multi-national, multi-ataxia consortia designed to measure communication change over time.

                                                                    Our paper on Automatic speech recognition in neurodegenerative disease was recently published in International Journal of Speech Technology.Automatic speech recognition...

                                                                      Redenlab are proud to support an upcoming randomized parallel group, placebo-controlled, dose-escalation clinical trial in Ataxia Telangiectasia

                                                                        Welcome Dr Noffs. Gustavo brings a wealth of clinical and research experience to the team, making contributions to tech development and science promotion, with a focus on his specialties of Parkinson’s disease and Multiple Sclerosis.

                                                                          Published in the European Journal of Human Genetics we expand the linguistic phenotype associated with SETBP1 LoF syndrome (SETBP1 haploinsufficiency disorder), revealing a striking speech presentation that implicates both motor (CAS, dysarthria) and language (phonological errors) systems, with CAS (80%) being the most common diagnosis.

                                                                            Redenlab’s Chief Science Officer (Prof Adam Vogel) presents at the symposia on Facial and Vocal Markers of CNS function, “Speech...

                                                                              Redenlab Inc. are excited to announce securing another clinical trial in Friedreich ataxia. Redenlab are providing speech analytics for a long-term open label extension clinical trial. Conducted in 8 sites across the USA over 2 years, the study will investigate the long-term efficacy of a treatment designed to ameliorate the debilitating impact of this fatal disease. For the study, Redenlab will provide advanced speech recording and analysis solutions.

                                                                                Redenlab Inc, the speech neuroscience company delivering insights in speech and language testing, announces that it has been selected by medium sized USA pharmaceutical company to support their upcoming gene therapy study in Friedreich ataxia (FA). Conducted across 5 sites in 3 countries over 2 years, the Phase 2a study will investigate the safety, tolerability and efficacy of gene therapy on adolescents with FA. For the study, Redenlab will provide advanced speech recording and analysis solutions.

                                                                                  Redenlab Inc, the speech neuroscience company delivering insights in communication testing, announces that it has been selected by USA and...

                                                                                    Hardware selection is a an important and often overlooked aspect of speech research

                                                                                      Objective: To determine whether specific speech, language and oromotor profiles are associated with different patterns of polymicrogyria (PMG), we assessed 52...
                                                                                        Highlights• Four children with heterozygous WAC pathogenic variants and epilepsy are described.• All children had global developmental impairment with language most severely...
                                                                                          Speech production relies on motor control and cognitive processing and is linked to cerebellar function. In diseases where the cerebellum...
                                                                                            ObjectivesTo systematically describe evidence on the use of instrumental swallowing assessment for residents of aged care homes.DesignScoping review using the...
                                                                                              AbstractObjectivesCognitive and other biases can influence the quality of healthcare decision making. While substantial research has explored how biases can...
                                                                                                PurposeTo identify outcome measurement tools used to evaluate communication, voice and speech intelligibility in the mechanically ventilated ICU population. Secondly,...

                                                                                                  Redenlab are glad to be supporting Larimar Therapeutics Inc. Phase 1 SAD clinical trial is a double-blind, placebo-controlled, randomized clinical trial to assess the safety of subcutaneously administered CTI-1601 versus placebo in adult subjects with Friedreich Ataxia.

                                                                                                    Redenlab are proud to be supporting PTC Therapeutics, Inc. Global Phase 3 Clinical Trial to Evaluate Vatiquinone in Friedreich Ataxia.

                                                                                                      Learn more about the platforms and applications that Redenlab use for software development, documentation, and quality management that is in-line with standards such as FDA 21 CFR Part 22.

                                                                                                        We are excited to announce that Redenlab Speech Scientists ranked top 1 AND 2 in the world for dysarthria (most common neuromuscular speech disorder)!

                                                                                                          SCA Global is a worldwide initiative for clinical research in spinocerebellar ataxias. Redenlab founder Adam Vogel will be presenting “Speech...
                                                                                                            Background & Motivation• Digital Endpoints/Biomarkers based on mobile devices and sensor technology are currentlybeing investigated in many clinical studies• Data...

                                                                                                              Redenlab has entered into a 5 year collaboration with investigators from North and South America, Australia and Europe to investigate the underlying neural mechanisms of Friedreich ataxia. The study is supported by the Friedreich's Ataxia Research Alliance (FARA) and pharmaceutical industry partners.

                                                                                                                Describing the relationship between disease severity and speech metrics, through listener-based and objective acoustic analysis.

                                                                                                                  In our new study, published in the Journal of Acoustical Society of America, we tested reliability, stability, and sensitivity to change in vowel measurements.

                                                                                                                    To explore the characteristics and associated factors of oromotor dysfunction in minimally verbal children with cerebral palsy (CP) aged five...
                                                                                                                      There is a lack of population‐based studies exploring the communicative behaviours of minimally verbal children with cerebral palsy (CP), with...
                                                                                                                        To examine the frequency, characteristics, and factors associated with speech delay and disorder in a community sample of children with...
                                                                                                                          Speech and swallowing deficits appear sensitive to disease progression in early-stage SCA2, with syllabic rate a viable marker. Findings provide...
                                                                                                                            BackgroundThere is a lack of population‐based studies exploring the communicative behaviours of minimally verbal children with cerebral palsy (CP), with...
                                                                                                                              Objective Determining the genetic basis of speech disorders provides insight into the neurobiology of human communication. Despite intensive investigation over the...
                                                                                                                                Despite the widespread use of nonword repetition in child neuropsychological research and clinical practice, the specific cognitive, linguistic and motor...
                                                                                                                                  What this paper addsWhat is already known on this subjectSpeech issues are common in children with hearing loss; however, the...
                                                                                                                                    What this paper addsSpeech and voice outcomes were similar between children born preterm and at term.Male sex, high social risk,...
                                                                                                                                      Highlights• Nonword repetition a sensitive clinical marker for DLD and DSD.• No significant differences in nonword repetition fMRI for DLD,...
                                                                                                                                        This chapter describes the diagnostic process necessary for the diagnosis and differential diagnosis of developmental disorders of speech and language...
                                                                                                                                          RationaleMotor neurone disease (MND) is a neurodegenerative disease presenting with progressive weakness of voluntary muscles. For any condition, person‐centred health...
                                                                                                                                            PurposeApproximately 30% of adults over the age of 50 years present with altered vocal function. Our understanding of how these...
                                                                                                                                              Dysphagia is common in Huntington’s disease (HD) affecting all phases of swallowing. Correlations exist between non-instrumental measures of dysphagia and...

                                                                                                                                                Article highlights

                                                                                                                                                • Dysarthria, a neuromuscular speech disorder, can be the first and most prominent manifestation of PD.

                                                                                                                                                • Alongside changes in speech, PD is associated with impaired morphosyntactic, lexical-semantic, and high-level language comprehension and production.

                                                                                                                                                • Pharmaceutical and surgical interventions for PD may improve certain modalities of speech production, but effects vary between individuals.

                                                                                                                                                • Longitudinal research designs are needed to evaluate the complex interplay between motor speech, language, and cognition.

                                                                                                                                                • Speech acoustics may serve as a valuable proxy marker of PD ‘risk’, disease progression and treatment efficacy.

                                                                                                                                                  Highlights

                                                                                                                                                  •Subtle but apparently genuine changes in speech occur in HD before clinical diagnosis.

                                                                                                                                                  •Speech changes in prodromal individuals are largely characterised by timing deficits.

                                                                                                                                                  •Limited longitudinal data restricts capacity to predict HD evolution using speech.

                                                                                                                                                    Highlights

                                                                                                                                                    •Measurable changes detected in swallowing function in 12 months

                                                                                                                                                    •Decline in function observed at three anatomical sites considered important for safe swallowing

                                                                                                                                                    •Individual anatomical sites may be precursors to widespread functional decline in swallowing

                                                                                                                                                      Redenlab scientists will be presenting at the upcoming meetings of #SPATAX & #MDSCongress in France on utility of #speech to...
                                                                                                                                                        BackgroundSubmucous cleft palate (SMCP) has a heterogeneous presentation and is often identified late or misdiagnosed. Diagnosis is prompted by speech,...
                                                                                                                                                          Clinical characteristics.Koolen-de Vries syndrome (KdVS) is characterized by developmental delay/intellectual disability, neonatal/childhood hypotonia, dysmorphisms, congenital malformations, and behavioral features. Psychomotor developmental delay...
                                                                                                                                                            Examination of rodent vocalizations in experimental conditions can yield valuable insights into how disease manifests and progresses over time. It...
                                                                                                                                                              Background. Communication impairment is one of the most common symptoms of Parkinson’s disease (PD), significantly affecting quality of life. Singing...
                                                                                                                                                                Autosomal-recessive cerebellar ataxias (ARCAs) comprise a heterogeneous group of rare degenerative and metabolic genetic diseases that share the hallmark of...
                                                                                                                                                                  BackgroundSubmucous cleft palate (SMCP) has a heterogeneous presentation and is often identified late or misdiagnosed. Diagnosis is prompted by speech,...
                                                                                                                                                                    PurposeThe purpose of this study was to expand the genetic architecture of neurodevelopmental disorders, and to characterize the clinical features...
                                                                                                                                                                      Background:Tremor is present in almost half of multiple sclerosis (MS) patients. The lack of understanding of its pathophysiology is hampering...
                                                                                                                                                                        Infants with a history of early, prolonged hospitalisation (e.g. due to preterm birth) are widely known to experience adverse neurodevelopmental...
                                                                                                                                                                          Children born preterm are at risk of impairments in oromotor control, with implications for early feeding and speech development. In...
                                                                                                                                                                            AbstractObjectiveThe study aim was to determine if use of illicit amphetamines or ecstasy is associated with abnormal excitability of the...
                                                                                                                                                                              Redenlab partnered with investigators in Australia and Germany to conduct dysarthria treatment trial in ataxia published in Journal of NeurologyAbstract:...
                                                                                                                                                                                Prof Angela Morgan of Murdoch Childrens Research Institute with Prof Barbara Dodd, partnering with Redenlab receive funding from the Victorian...
                                                                                                                                                                                  BackgroundSpeech and language deficits are frequent in males with Klinefelter syndrome (KS), yet the research base is slim and specific...
                                                                                                                                                                                    Working with clinician-scientists from UCSF Memory and Aging Center, Redenlab are providing services to help track changes in disease state...
                                                                                                                                                                                      Neurexin 1 gene (NRXN1) deletions are associated with several neurodevelopmental disorders. Communication difficulties have been reported, yet no study has...
                                                                                                                                                                                        IMPORTANCE:Multiple sclerosis produces neurological impairments that are variable in duration, severity and quality. Speech is frequently impaired, resulting in decreased...
                                                                                                                                                                                          BACKGROUND:Frontotemporal lobar degeneration (FTLD) can result in a decline in behavior, language, and motor function. Mealtime disturbances are a common...
                                                                                                                                                                                            Few studies have examined growth and predictors of receptive vocabulary in children with autism spectrum disorder. Here we aimed to...
                                                                                                                                                                                              PURPOSE:Language skills are critical. Children born very preterm are vulnerable to language problems, but further work is needed to determine...
                                                                                                                                                                                                CASE HISTORY:A 5-year-old girl presented with a suspected palatal abnormality, first observed by her general practitioner during a routine examination at...
                                                                                                                                                                                                  BACKGROUND:The association between left hemisphere stroke and acute speech and language impairment is well documented in adults. However, little is...
                                                                                                                                                                                                    OBJECTIVE:Subclinical phenotypes of nonsyndromic cleft lip with or without cleft palate (CL ± P) may be identified from clinically "unaffected"...
                                                                                                                                                                                                      AIM:We aimed to systematically review the speech production, language, and oral function phenotype of bilateral perisylvian polymicrogyria (BPP), and examine...
                                                                                                                                                                                                        BACKGROUND:Childhood apraxia of speech (CAS) affects a child's ability to produce sounds and syllables precisely and consistently, and to produce...
                                                                                                                                                                                                          Published in Journal of Autism and Developmental Disordershttps://link.springer.com/article/10.1007%2Fs10803-018-3565-2 This study used a prospective community-based sample to describe patterns and predictors of...
                                                                                                                                                                                                            Published in Journal of Pediatricshttps://www.sciencedirect.com/science/article/pii/S0022347618302944ObjectiveTo characterize the organization of speech- and language-related white matter tracts in children with developmental speech...
                                                                                                                                                                                                              The purpose of this consensus paper is to review electrophysiological abnormalities and to provide a guideline of neurophysiological assessments in...
                                                                                                                                                                                                                Objective: To analyze the oral motor, speech, and language phenotype in 20 children and adults with Dravet syndrome (DS) associated with...
                                                                                                                                                                                                                  Communication disorder is common in Koolen de Vries syndrome (KdVS), yet its specific symptomatology has not been examined, limiting prognostic...
                                                                                                                                                                                                                    Speech sound disorder (SSD) is common, yet its neurobiology is poorly understood. Recent studies indicate atypical structural and functional anomalies...
                                                                                                                                                                                                                      The SWAL-QOL questionnaire is a common tool for evaluating patients' dysphagia-specific quality of life. A validated German version is not...
                                                                                                                                                                                                                        PURPOSE:The purpose of this study is to assess Cantonese word recognition and the discrimination of Cantonese tones with manipulated contours...
                                                                                                                                                                                                                          Recurrent deletions of a ~600-kb region of 16p11.2 have been associated with a highly penetrant form of childhood apraxia of...
                                                                                                                                                                                                                            Comprehensive description of motor speech function in behavioral variant frontotemporal dementia (bvFTD)One in 8 patients presented with moderate speech timing...
                                                                                                                                                                                                                              HighlightsCannabis users exhibit increased angular velocity of the knee during walking gait.Cannabis users exhibit reduced shoulder flexion during walking gait.Gait...
                                                                                                                                                                                                                                In collaboration with the Movement Disorders and Cognitive monitoring in MS group. Speech is being used as an outcome measure...
                                                                                                                                                                                                                                  Redenlab are partnering with Koneksa Health to provide speech testing to Takeda Pharmaceuticals USA on a multi-site trial across the...
                                                                                                                                                                                                                                    https://www.ncbi.nlm.nih.gov/pubmed/28678079Objectives: The ability to recognize tones is vital for speech perception in tonal languages. Cantonese has six tones, which are...
                                                                                                                                                                                                                                      • 100% of patients with POLG-A present with dysarthria and dysphagia• POLG patients without ataxia do not present with speech or swallowing...
                                                                                                                                                                                                                                        Speech sensitive to treatment responseJ Neurol. 2015 May;262(5):1344-53. doi: 10.1007/s00415-015-7719-2
                                                                                                                                                                                                                                          Localization of language deficitsNeurology. 2017 Mar 7;88(10):924-925. doi: 10.1212/WNL.0000000000003705. 
                                                                                                                                                                                                                                            Does speech change in pre-manifest HD?Neurology. 2016 Nov 22;87(21):2283
                                                                                                                                                                                                                                              The model has high discriminative ability to distinguish between cases with and without AOS (c-index=0.93) and good agreement between observed...
                                                                                                                                                                                                                                                Using acoustic analysis of speech may lead to improved diagnostic accuracy.J Alzheimers Dis. 2016 Apr 19;53(1):79-83. doi: 10.3233/JAD-160069.
                                                                                                                                                                                                                                                  The relationship between dysphonia and dysarthria in FRDA suggests that reducing overall dysphonia severity via therapeutic techniques that improve phonatory...
                                                                                                                                                                                                                                                    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in reducing motor symptoms for many individuals with Parkinson's...
                                                                                                                                                                                                                                                      Measures of speech which can assist with diagnosis and classification in FTD, PPA, and progressive apraxia of speech. J Speech Lang...
                                                                                                                                                                                                                                                        The CADN is a reliable, valid, brief, quantifiable, and easily deployed assessment of swallowing in neurodegenerative disease. It is thus...
                                                                                                                                                                                                                                                          Intra-individual changes in speech were detected as a response to modified amplitudeFront Bioeng Biotechnol. 2015 Jul 14;3:98. doi: 10.3389/fbioe.2015.00098
                                                                                                                                                                                                                                                            The Huntington Study Group is taking the early and proactive step of moving this year’s annual meeting, HSG 2020: HD...