Our Latest Publications
The role of verbal fluency in the cerebellar cognitive affective syndrome scale in Friedreich Ataxia
What are the evidence-based recommendations to guide early intervention in children aged 0 to 2 years who have or are at high risk of cerebral palsy?
Redenlab pediatric specialist Prof Angela Morgan co-authors a new study on speech models in minimally verbal children with autism spectrum disorder. The collaboration with scientists from Boston and Melbourne provides preliminary evidence that subphenotypes of children with MV ASD may exist.
Acoustic features that predict healthy aging are different than those previously reported for the pathologic voice. We propose a model of healthy and pathologic voice development in which voice characteristics are mediated by the inability to monitor vocal productions associated with age-related hearing loss.
Miglustat is currently the only approved disease-specific treatment shown to be effective in stabilizing neurological symptoms. Miglustat has previously been reported to halt or improve early dysphagia and cognitive symptoms. Here we examine the characteristics of dysphagia, the relationship between dysphagia and the presence of cognitive impairment, and longitudinal changes in swallowing function during miglustat treatment in adult-and-adolescent-onset NPC.
Redenlab CSO contributes to a new book chapter on the Best practices for supervised machine learning when examining biomarkers in clinical populations has been included in ‘Big Data in Psychiatry & Neurology’ published by Elsevier.
FOXP1-related disorder is characterized by a complex speech and language phenotype with prominent dysarthria, broader motor planning and programming deficits, and linguistic-based phonological errors. Diagnosis of the speech phenotype associated with FOXP1-related dysfunction will inform early targeted therapy.
Published in the European Journal of Human Genetics we expand the linguistic phenotype associated with SETBP1 LoF syndrome (SETBP1 haploinsufficiency disorder), revealing a striking speech presentation that implicates both motor (CAS, dysarthria) and language (phonological errors) systems, with CAS (80%) being the most common diagnosis.
Hardware selection is a an important and often overlooked aspect of speech research
Describing the relationship between disease severity and speech metrics, through listener-based and objective acoustic analysis.
In our new study, published in the Journal of Acoustical Society of America, we tested reliability, stability, and sensitivity to change in vowel measurements.
Article highlights
-
Dysarthria, a neuromuscular speech disorder, can be the first and most prominent manifestation of PD.
-
Alongside changes in speech, PD is associated with impaired morphosyntactic, lexical-semantic, and high-level language comprehension and production.
-
Pharmaceutical and surgical interventions for PD may improve certain modalities of speech production, but effects vary between individuals.
-
Longitudinal research designs are needed to evaluate the complex interplay between motor speech, language, and cognition.
-
Speech acoustics may serve as a valuable proxy marker of PD ‘risk’, disease progression and treatment efficacy.
Highlights
•Subtle but apparently genuine changes in speech occur in HD before clinical diagnosis.
•Speech changes in prodromal individuals are largely characterised by timing deficits.
•Limited longitudinal data restricts capacity to predict HD evolution using speech.
Highlights
•Measurable changes detected in swallowing function in 12 months
•Decline in function observed at three anatomical sites considered important for safe swallowing
•Individual anatomical sites may be precursors to widespread functional decline in swallowing